In Vitro Adme

DMPK studies are conducted to determine the disposition of the drug and its metabolites using suitable animal models. At CHEMRTL we offer the following DMPK services

–  Single or multiple dose (s) – in mice & rats

–  Oral &/or IV or IP (or intended) route

–  2-6 animals/dose; 5-12 time points / client specific designs

–  PK study in cannulated animals as per client’s requirement

–  Tissue distribution studies

–  In -vivo blood – brain barrier penetration studies

End-points

–  Oral BA

–  Elimination half life (t1/2) Renal Clearance (Cl) Volume Distribution (Vd), AUC, Under Area Curve; Maximum Plasma Concentration;

–  Metabolite identification